First‐Pass Effect With Aspiration Thrombectomy With the Penumbra System in Patients With Acute Ischemic Stroke: A Core Laboratory–Adjudicated Subset Analysis of the COMPLETE Registry

Background In patients with acute ischemic stroke, minimizing the time to revascularization can minimize neuronal death. First‐pass effect (FPE), defined as successful or complete of an occluded target vessel 1 pass a mechanical thrombectomy device(s), reduces revascularization. The objective this study was determine FPE rate, compare cases in which versus not achieved, and predictors good functional outcome at 90 days, large‐vessel occlusion stroke treated Penumbra System (Penumbra, Inc). Methods This is subset analysis COMPLETE (International Acute Ischemic Stroke Registry With Aspiration Including 3D [3‐Dimensional] Revascularization Device) registry, global, prospective, multicenter, observational registry. rates were calculated. Subgroups who achieved did achieve compared. Variables independently associated days determined. Results A total 648 included. definition modified thrombolysis cerebral infarction score 2b 3 56.8% patients, 2c 41.5%, 31.8%. percentage higher for than ( P <0.01). Achieving independent predictor (adjusted odds ratio, 1.64; =0.045). Conclusions For aspiration System, achieving significantly rate outcome.